Infectious disease caused by coronavirus (COVID-19) in pregnant women and newborns: clinical impact and recommendations
Section: Revisiones
How to quote
Serna García C, Moreno Sánchez V, González Cintora M, Cruz Fernández JM. Enfermedad infecciosa por coronavirus (COVID-19) en la mujer embarazada y el neonato: impacto clínico y recomendaciones. Metas Enferm jun 2020; 23(5):22-32. Doi: https://doi.org/ 10.35667/MetasEnf.2019.23.1003081597
Authors
Carmen Serna García1, Víctor Moreno Sánchez2, Miren González Cintora2, José Manuel Cruz Fernández3
Position
1Graduada en Enfermería. Especialista en Obstetricia y Ginecología. Hospital Ernest Lluch Martin. Calatayud (Zaragoza) 2Graduado en Enfermería. Especialista en Obstetricia y Ginecología. Hospital Clínico Universitario Lozano Blesa. Zaragoza3Graduado en Enfermería. Especialista en Obstetricia y Ginecología. Hospital Universitario de Basurto. Bilbao
Contact address
Carmen Serna García. Hospital Ernest Lluch Martin. Ctra. de Sagunto-Burgos, Km. 254. 50300 Calatayud (Zaragoza).
Contact email: carmen.serna.garcia@gmail.com
Abstract
Objective: to collect and confirm the scientific information available regarding SARS-CoV-2 during the gestational process and its effects on the obstetric patient during delivery and puerperium, and on the newborn.
Method: a bibliographic review of the evidence available was conducted in three international databases: PubMed, Science Direct and Cochrane. Standardized terms were used, as well as free language, synonyms and truncation, combining them with Boolean operators based on the capacity of each database. Likewise, the webpages of official organizations and scientific societies addressing the matter of pregnancy and COVID-19 were also consulted.
Results: in total, 14 articles and 9 clinical practice guidelines were selected, as well as technical reports from different national and international organizations. There is limited bibliography, and with low scientific evidence, given the novelty of the pandemic caused by this coronavirus, but scientific documents were retrieved which addressed pregnancy and fetus, delivery, puerperium and newborns. It is believed that the SARS-CoV-2 virus has less adverse reactions in the pregnant woman and her newborn than other viruses from the same class. Each pregnant woman infected and her newborn should be subject to early identification and evaluation, in an individual and multidisciplinary way, in order to prevent adverse results and complications. There is no evidence of the vertical transmission of the SARS-CoV-2 virus. There are discrepancies regarding the management of newborns of pregnant women infected by COVID-19.
Conclusion: there are many knowledge gaps regarding the management of pregnant women, delivery, puerperium and newborns, because there is limited evidence available.
Keywords:
pregnancy; newborn; neonate; COVID-19; SARS-CoV-2; coronavirus
Versión en Español
Título:
Artículo completo no disponible en este idioma / Full article is not available in this language
Bibliography
- World Health Organization. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-2019) [internet] 16-24 febrero 2020 [citado 8 may 2020]. Disponible en: https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf
- Ministerio de Sanidad. Enfermedad por Nuevo Coronavirus, COVID-19 [internet]. Madrid: Ministerio de Sanidad; 31 de diciembre de 2019 [citado 8 mayo 2020]. Disponible en: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Informacion_inicial_alerta.pdf
- World Health Organization. Coronavirus disease (COVID-19) situation reports. Situation report-83 [internet]. Ginebra: WHO; 2020. [citado 12 abril 2020]. Disponible en: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/
- Ministerio de Sanidad. Situación del COVID-19 en España [internet]. Madrid: Ministerio de Sanidad; 2020 [citado 8 mayo 2020]. Disponible en: https://covid19.isciii.es/
- Dashraath P, Jing Lin Jeslyn W, Mei Xian Karen L, Li Min L, Sarah L, Biswas A, et al. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Am. J. Obstet. Gynecol. [internet] marzo 2020 [citado 8 may 2020] S0002-9378(20). Disponible en: https://www.ajog.org/article/S0002-9378(20)30343-4/fulltext
- Ministerio de Sanidad. Documento técnico. Manejo de la mujer embarazada y el recién nacido con COVID-19 [internet]. Madrid: Ministerio de Sanidad; 2020 [versión 13 de mayo de 2020; citado 8 mayo 2020]. Disponible en: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Documento_manejo_embarazo_recien_nacido.pdf
- Schwartz DA, Graham AL. Potential maternal and infant outcomes from (Wuhan) coronavirus 2019-ncov infecting pregnant women: lessons from SARS, MERS and other human coronavirus infection. Viruses. 2020; 12(2):E194. Doi: http://doi.org/10. 3390/v12020194.
- Zhonghua Liu Xing Bing Xue Za Zhi. Vital surveillances: the epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19)–in China. China CDC Weekly. Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. 2020; 41(2):145-51. Doi: http://doi.org/10.3 760/cma.j.issn.0254-6450.2020.02.003
- Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine. 2020; (20)2213-600. Doi: http://doi.org/10.1016/S2213-2600(20)30079-5
- World Health Organization (WHO). Clinical managemente of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Interim guidance. Reference number: WHO/2019-nCoV/clinical/2020.4 [internet]. Ginebra: WHO; 2020 [citado 8 may 2020]. Disponible en: https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected
- Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet 2020; 395(10223):497-506. Doi: https://doi.org/10. 1016/S0140-6736(20)30183-5
- Centers for Disease Control and Prevention. Coronavirus Disease 2019 [internet] [citado 20 marzo 2020]. Disponible en: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/pregnancy-breastfeeding.html
- Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, et al. Outcome of Coronavirus spectrum infection (SARS, MERS, COVID1-19) during pregnancy: a systematic review and meta-analysis. Am. J. Obstet. Gynecol. MFM. 2020. Doi: http://doi.org/10.101 6/j.ajogmf.2020.100107
- Del Pino Casado R. La búsqueda bibliográfica en el trabajo de fin de grado. En: Del Pino Casado R, Martínez Riera JR (eds.). Manual para la elaboración y defensa del trabajo de fin de grado en ciencias de la salud. Madrid: Elsevier; 2016. p. 25-40.
- Chen H, Gue J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. The Lancet [internet] 2020 [citado 8 may 2020] 395(10226):809-15. Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS014 0-6736(20)30360-3/fulltext
- Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Translational Pediatrics [internet] 2020 [citado 8 may 2020] 9(1). Disponible en: http://tp.amegroups.com/article/view/35 919/28274
- Sociedad Española de Obstetricia y Ginecología (SEGO). Recomendaciones para la prevención de la infección y el control de la enfermedad por coronavirus 2019 (COVID-2019) en la paciente obstétrica. Madrid: SEGO; 2020.
- European Centre for Disease Control [internet] Coronavirus disease 2019 (COVID-19) pandemic: increased transmission in the EU/EEA and the UK–seventh update [citado 8 may 2020]. Disponible en: https://www.ecdc.europa.eu/sites/default/files/documents/RRA-seventh-update-Outbreak-of-coronavirus-disease-COVID-19.pdf
- Chen Y, Peng H, Wang L, Zhao Y, Zeng L, Gao H, Liu Y. Infants born to mothers with a new coronavirus (COVID-19). Frontiers in Pediatrics. 2020. Doi: https://doi.org/10.3389/fped.2020.00104
- Chen S, Liao E, Cao D, Gao Y, Guoqiang S, Shao Y. Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. Journal of Medical Virology [internet] 2020 [citado 8 may 2020]. p. 1-6. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.100 2/jmv.25789
- Schwartz, David. An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. Archives of Pathology & Laboratory Medicine In-Press. [internet] 2020 [citado 8 may 2020]. Doi: https://doi.org/10.5858/arpa.2020-0901-SA
- Zhang L, Juang Y, Wei M, Cheng BH, Zhou XC, Li J, et al. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. PubMed. 2020; 55(0):E009. Doi https://doi.org/10.376 0/cma. j.cn112141-20200218-00111
- Chen S, Huang B, Luo DJ, Li X, Yang F, Zhao F, Nie X, Huang BX. Pregnant women with new coronavirus infection: a clinical characteristics and placental pathological analysis of three cases. 2020; 49(0). Doi: https://doi.org/10.3760/cma.j.cn11215 1-2020 0225-00138
- Liu W, Wang Q, Zhang Q, Chen L, Chen J, Zhang B, et al. Coronavirus Disease 2019 (COVID-19) During Pregnancy: A Case Series. Preprints [internet] 2020 [citado 8 may 2020] Version 1:202002.0373.v1. Disponible en: https://www.preprints.org/manuscript/202002.0373/v1
- Chen D, Yang H, Cao Y, Cheng W, Duan T, Fan C, et al. Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection. BJOG [internet] 2020 [citado 10 abril 2020]. 149(2):130-6. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/32196655
- Poon LC, Yang H, Lee JCS, Copel JA, Leung TY, Zhang D, et al. ISUOG Interim Guidance on 2019 novel coronavirus infection during pregnancy and puerperium: information for healthcare professionals. Ultrasound in Obstetrics & Gynecology [internet] 2020 [citado 8 may 2020]. Disponible en: https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1002/uog.22013
- Sociedad Española de Neonatología (SEN). Recomendaciones para el manejo del recién nacido en relación con la infección por SARS-CoV-2. Versión 5.0 [internet] marzo [citado 8 may 2020] 2020. Disponible en: https://www.se-neonatal.es/~josepr23/sociedades/SENEOv1/images/site/noticias/home/Recomendaciones_SENeo_SARS-CoV-2Version_50.pdf
- Liang H, Acharya G. Novel coronavirus disease (COVID-19) in pregnancy: What clinical recommendations to follow. Acta Obstetricia et Gynecologica Scandinavia [internet] 2020 [citado 8 may 2020]. 99(4). Disponible en: https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/aogs.13836
- Sociedad Española de Obstetricia y Ginecología. Posicionamiento de la Sociedad Española de Ginecología y Obstetricia y de su Sección de Medicina Perinatal ante las noticias de mala praxis en gestantes con COVID-19. Madrid: SEGO; 2020.