Metas de Enfermería

Metas de Enfermería

ABRIL 2007 N° 3 Volumen 10

Heparinised solution versus physiologic solution for permeability of peripheral routes

Section: Cover story

How to quote

Castells Molina M, Gómez Valiente MA, Ávila Olivares JA, Picazo Mollá MT. Solución heparinizada versusfisiológica para la permeabilidad de vías periféricas. Metas de Enferm abr 2007; 10(3): 29-31 0230


Miguel Castells Molina, Mª Ángeles Gómez Valiente2, José Antonio Ávila Olivares3, Mª Teresa Picazo4


Enfermero. Supervisor Unidad de Neumología, Enfermera. Unidad de Neumología2, Enfermero en departamento 203, Enfermera en a Unidad de Cirugía Torácica4

Contact address

Unidad de Neumología. Hospital General Universitario de Alicante (HGUA). C/ Pintor Baeza, s/n. 03010 Alicante.

Contact email: miguel.castells@ua.es


Objective: to objectify the scientific evidence on the use of physiologic solution or heparinised solution for the cleansing and maintenance of venous catheters requiring peripheral access routes.
Material and method: a narrative review was carried out. A bibliography search was performed on the Internet in English-speaking databases (Cochrane Library y Medline) and Spanish-speaking databases (CUIDEN, BDIE and Cuidatge), with tag words: “heparin”, “Sodium Chloride”, “peripheral venous catheter”, “cost”, “intravenous infusions” , “sodium heparin”, “Sodium Chloride”, “peripheral venous
catheter”, “cost” and “fluid therapy”.
Results: several studies demonstrated the disadvantages of using heparinised physiologic solution vs physiologic solution alone for the permeabilisation of peripheral venous catheters. Reviews on the subject did not reveal any significant differences in the incidence of phlebitis and obstruction in trials that used a concentration of 10UI/ml of heparinised physiologic solution vs physiologic solution alone. The recommendation of the American Society of Hospital Pharmacists advocates the use of physiologic solution alone against heparinised solution, since the first has been associated with the same level of efficacy, fewer adverse effects, no incompatibility with other drugs and lower costs as compared to the latter.
Conclusions: the study of reviewed studies does not show any significant differences justifying the use of heparinised physiological solution vs physiologic solution for the maintenance of PVC (peripheral venous catheters). Based on this finding, the use of physiological solution is recommended in the majority of cases since it has proven to be as effective as heparinised solution and with no adverse effects. Nonetheless, there are no unified criteria for the correct administration of physiologic solution, and thus further specific studies on this subject should be conducted.

Versión en Español


Solución hepanizada versus fisiología para la permeabilidad de vías periféricas.