The aim of this paper is to analyze the quality of life of patients that have had a stroke using the following theories: General Systems Theory, Chaos Theory, and Complexity Theory, as an answer to this type of neurological alteration. The complex functioning of the human body causes the individual to experience a state of maximal entropy (disorder and chaos), which will result in motor and/or sensitive deficit and is the principal cause of disability and incapacity in the body, to reach at a later stage a state of maximal neguentropy. The fundament of this analysis is based on the personal clinical experience I have acquired through several years of caring for these patients and also to a research initiative that basically determines the circumstances that cause these patients the greatest disabilities and, thus, have an impact on their quality of life, as well as the complaints that are most commonly reported to the nursing professional during follow-up visits. And lastly, their new self-organisation from an inter and transdisciplinary approach.