Pain is an inherent feature in labor and delivery and is one of the main aspects overshadowing the unequalled experience of giving birth to a newborn baby. There is a current consensus on using epidural analgesia as an ideal method for pain management during labor because pain relief is achieved while motor capacity is well preserved, allowing the mother to actively participate in such a rewarding experience. Additionally, epidural analgesia has shown the best risk/benefit ratio, with minimal effects on the fetus and on labor and delivery course. Emergence of new information on epidural analgesia and its complications, along with a current trend to achieve a consistent higher professional level in nurses providing such care, have resulted in an increasing education and updating commitment in this field. Nursing staff involved in labor and delivery or postpartum care must have a clear-cut knowledge of epidural technique’s special features and potential complications, so that they can take decisions and perform procedures based on a solid scientific foundation. The present paper is intended to provide professional nursing staff (both specialists [midwives] and nurses in Anesthesia Units, Postpartum Units, and others) with an updated knowledge as a guide for pregnant women care using epidural analgesia, both for anesthetic block implementation and for subsequent monitoring.