Obesity, perinatal nutrition and epigenetics
Section: Aula
How to quote
Cordero P. Obesidad, nutrición perinatal y epigenética. Matronas hoy 2014; 2(1):41-9.
Authors
Paul Cordero
Position
Doctor en Farmacia. Departamento de Ciencias de la Alimentación y Fisiología. Facultad de Farmacia. Universidad de Navarra (Pamplona)
Contact email: pcordero@alumni.unav.es
Abstract
Obesity has been defined as the twenty-first century pandemic. Its increasing prevalence and associated disorders have prompted approaching obesity as a priority by Healthcare System. Furthermore, physiologic state in obesity during pregnancy is associated to a number of pregnancy problems both for the mother and for offspring appropriate development. Epidemiological studies have also reported that maternal nutritional state changes have an impact on newborn characteristics and on the risk for metabolic diseases in adulthood. Mechanisms involved in such processes can be explained by epigenetics, a key tool in gene expression regulation. Due to methodological difficulties and ethical implications when performing perinatal procedures, experimental animal models are the main tools to reach an understanding of mechanisms involved in it. Its main objective is to search for biomarkers associated to maternal diet as a diagnostic tool for risk recognition and adult diseases in offspring. In conclusion, not only are we what we eat, we are also what our mothers ate, through an effect that is passed to next generation. Reaching an appropriate weight for gestational age, and having a healthy diet and lifestyle during pregnancy and lactation help to promote offspring development and to reduce their risk for obesity and associates metabolic diseases.
Keywords:
pregnancy; malnutrition; maternal programming; DNA methylation; child obesity
Versión en Español
Título:
Artículo completo no disponible en este idioma / Full article is not available in this language
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