3
Revista Matronas

Revista Matronas

DICIEMBRE 2024 N° 3 Volumen 12

The vaginal microbiota as a reflection of female reproductive tract health: a new element to be considered within care provided by midwives

Section: Revisions

How to quote

Méndez-Haxlasabeau I, Pérez-Pérez C, Villarroel-Espíndola F. Microbiota vaginal, reflejo de la salud del tracto reproductor femenino: un nuevo elemento a considerar en la atención prestada por matronas. Matronas Hoy 2024; 12(3):39-45.

Authors

1 Isabel Méndez-HaxIsabeau, 2 Carolina Pérez-Pérez, 3 Franz Villarroel-Espíndola

Position

1 Matrona. Hospital Universitario Poniente. El Ejido (Almería). Magíster en Docencia en Educación Superior. Académica Instructora en la Carrera de Obstetricia. Facultad de Ciencias para el Cuidado de la Salud. Universidad San Sebastián. Providencia. Santiago (Chile). 2 Licenciada en Obstetricia (Matrona). Magíster en Educación mención Gestión de Centros Educativos. Magíster en Intervención Psicológica del Desarrollo y Educación. Académica Asistente en la Carrera de Obstetricia. Facultad de Ciencias para el Cuidado de la Salud. Universidad San Sebastián. Providencia. Santiago (Chile). 3 Licenciado en Bioquímica. Doctorado en Ciencias mención Biología Celular y Molecular. Posdoctorado en Inmuno- Oncología Traslacional en Universidad de Yale, New Haven, EE.UU. Posdoctorado en Metabolismo Celular en Universidad Austral de Chile, Valdivia, Chile. Investigador principal y jefe de la Unidad de Medicina Traslacional de Fundación Arturo López Pérez (FALP). Providencia, Santiago-RM (Chile).

Contact email: isabeau.mendez@uss.cl

Abstract

Introduction: vaginal microbiota (VM) is an essential compo-
nent in female reproductive health, acting as a mechanism of
defence against infections and diseases, including cancer. Lac-
tobacilli are the most prevalent and prevailing microorganisms
in this microbiota, and their presence has been associated with
a healthy vaginal environment. However, the dysbiosis charac-
terized by a reduction in lactobacilli and an increase in other
microorganisms can predispose women to infections, such as
the infection by the human papilloma virus (HPV), which is a
known factor of risk for development of cervical cancer.
Objective: to reinforce the importance of vaginal microbio-
ta and its composition as a factor determining the health
status of the female tract and its potential consequences in
female reproductive health, and as an essential element that
midwives must pay special attention to in their obstetric-gy-
naecological activity of care.
Methodology: a qualitative bibliographic review on articles
published about the connection between intestinal micro-
biome and the reproductive tract between 2010 and 2024.
Discussion and Conclusions: vaginal microbiota is an essen-
tial component of female reproductive health; midwives are
aware of this and can help women to maintain a healthy
vaginal environment, preventing infections, and to avoid
dysbiosis during pregnancy and childbirth.

Keywords:

vaginal microbiota; lactobacilli; HPV; vaginal conditions; cancer; vaginal infections; dysbiosis; midwives

Versión en Español

Título:

Microbiota vaginal, reflejo de la salud del tracto reproductor femenino: un nuevo elemento a considerar en la atención prestada por matronas

Artículo completo no disponible en este idioma / Full article is not available in this language

Bibliography

1. Clarke BL, Khosla S. Female reproductive system and bone. Arch Biochem Biophys [internet] 2010 [citado 8 dic 2024]; 503(1):118-28. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC2942975/
2. Morton DA, Foreman KB, Albertine KH. Anatomía macroscópica. Un panorama general 2ª ed. [internet]. Madrid: McGraw Hill Education Inc.; 2022. [citado 8 dic 2024]. Disponible en: https://accessmedicina.mhmedical.com/content.aspx?bookid=3211&sectionid=268975917
3. Monin L, Whettlock EM, Male V. Immune responses in the human female reproductive tract. Immunology [internet]. 2020 [citado 8 dic 2024]; 160(2):106-15. Disponible en: https://onlinelibrary.wiley.com/doi/10.1111/imm.13136
4. Sirota I, Zarek SM, Segars JH. Potential influence of the microbiome on infertility and assisted reproductive technology. Semin Reprod Med [internet] 2014 [citado 8 dic 2024]; 32(1):35-42. Disponible en: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0033-1361821
5. Abou Chacra L, Fenollar F, Diop K. Bacterial vaginosis: What do we currently know? Front Cell Infect Microbiol [internet]. 2022 [citado 8 dic 2024]; 11:672429. Disponible en: https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.672429/full
6. Champer M, Wong AM, Champer J, Brito IL, Messer PW, Hou JY, et al. The role of the vaginal microbiome in gynaecological cancer. BJOG [internet]. 2018 [citado 8 dic 2024]; 125(3):309-15. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28278350/
7. Kalia N, Singh J, Kaur M. Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review. Ann Clin Microbiol Antimicrob [internet]. 2020 [citado 8 dic 2024]; 19(1):5. Disponible en: https://ann-clinmicrob.biomedcentral.com/articles/10.1186/s12941-020-0347-4
8. Borges S, Silva J, Teixeira P. The role of lactobacilli and probiotics in maintaining vaginal health. Arch Gynecol Obstet [internet]. 2014 [citado 8 dic 2024]; 289(3):479-89. Disponible en: https://medipharmavision.cz/media/studie/Gynekologick%C3%A9%20poti%C5%BEe/The%20role%20of%20lactobacilli%20and%20probiotics%20in%20maintaining%20vaginal%20health.pdf
9. Ursell LK, Clemente JC, Rideout JR, Gevers D, Caporaso JG, Knight R. The interpersonal and intrapersonal diversity of human-associated microbiota in key body sites. J Allergy Clin Immunol [internet]. 2012 [citado 8 dic 2024]; 129(5):1204-8. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC3342686/
10. Braundmeier AG, Lenz KM, Inman KS, Chia N, Jeraldo P, Walther-António MRS, et al. Individualized medicine and the microbiome in reproductive tract. Front Physiol [internet]. 2015 [citado 8 dic 2024]; 6:97. Disponible en: https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2015.00097/full
11. Saraf VS, Sheikh SA, Ahmad A, Gillevet PM, Bokhari H, Javed S. Vaginal microbiome: normalcy vs dysbiosis. Arch Microbiol [internet] 2021 [citado 8 dic 2024]; 203(7):3793-802. Disponible en: https://www.researchgate.net/publication/352379607_Vaginal_microbiome_normalcy_vs_dysbiosis
12. Chee WJY, Chew SY, Than LTL. Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health. Microb Cell Fact [internet]. 2020 [citado 8 dic 2024]; 19(1):203. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC7648308/
13. Amabebe E, Anumba DOC. Psychosocial stress, cortisol levels, and maintenance of vaginal health. Front Endocrinol (Lausanne) [internet]. 2018 [citado 8 dic 2024]; 9:568. Disponible en: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00568/full
14. Lewis FMT, Bernstein KT, Aral SO. Vaginal microbiome and its relationship to behavior, sexual health, and sexually transmitted diseases. Obstet Gynecol [internet]. 2017 [citado 8 dic 2024]; 129(4):643-54. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC6743080/
15. Deka N, Hassan S, Seghal Kiran G, Selvin J. Insights into the role of vaginal microbiome in women’s health. J Basic Microbiol [internet]. 2021 [citado 8 dic 2024]; 61(12):1071-84. Disponible en: https://www.researchgate.net/publication/356167284_Insights_into_the_role_of_vaginal_microbiome_in_women’s_health
16. Auriemma RS, Scairati R, Del Vecchio G, Liccardi A, Verde N, Pirchio R, et al. The vaginal microbiome: A long urogenital colonization throughout woman life. Front Cell Infect Microbiol [internet] 2021 [citado 8 dic 2024]; 11:686167. Disponible en: https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.686167/full
17. Ventolini G, Vieira-Baptista P, De Seta F, Verstraelen H, Lonnee-Hoffmann R, Lev-Sagie A. The Vaginal Microbiome: IV. The role of vaginal microbiome in reproduction and in gynecologic cancers. J Low Genit Tract Dis [internet]. 2022 [citado 8 dic 2024]; 26(1):93-8. Disponible en: https://journals.lww.com/jlgtd/fulltext/2022/01000/the_vaginal_microbiome__iv__the_role_of_vaginal.18.aspx
18. Cheng L, Gao Y, Xia Q, Wang H, Xie X, Liu Y, et al. Reproductive tract microbiota of women in childbearing age shifts upon gynecological infections and menstrual cycle. BMC Microbiol [internet]. 2021 [citado 8 dic 2024]; 21(1):252. Disponible en: https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-021-02300-4
19. Lee JE, Lee S, Lee H, Song Y-M, Lee K, Han MJ, et al. Association of the vaginal microbiota with human papillomavirus infection in a Korean twin cohort. PLoS One [internet]. 2013 8(5):e63514. Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063514
20. Wang H, Jiang Y, Liang Y, Wei L, Zhang W, Li L. Observation of the cervical microbiome in the progression of cervical intraepithelial neoplasia. BMC Cancer [internet]. 2022 [citado 8 dic 2024]; 22(1). Disponible en: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09452-0
21. Santella B, Schettino MT, Franci G, De Franciscis P, Colacurci N, Schiattarella A, et al. Microbiota and HPV: The role of viral infection on vaginal microbiota. J Med Virol [internet]. 2022 [citado 8 dic 2024]; 94(9):4478-84. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC9544303/
22. Xia Y, Feng Y, Qin T, Zhao X, Lu J, Ma C. Characteristics of vaginal microbiome in reproductive-age females with HPV infection in Xinjiang, China. Evid Based Complement Alternat Med [internet]. 2022 [citado 8 dic 2024]; 7332628. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC9643059/
23. Chen T, Xia C, Hu H, Wang H, Tan B, Tian P, et al. Dysbiosis of the rat vagina is efficiently rescued by vaginal microbiota transplantation or probiotic combination. Int J Antimicrob Agents [internet]. 2021 [citado 8 dic 2024]; 57(3):106277.     Disponible en: https://www.researchgate.net/publication/348412877_Dysbiosis_of_rat_vagina_is_efficiently_rescued_by_the_vaginal_microbiota_transplantation_or_probiotic_combination
24. Adapen C, Réot L, Menu E. Role of the human vaginal microbiota in the regulation of inflammation and sexually transmitted infection acquisition: Contribution of the non-human primate model to a better understanding? Front Reprod Health [internet]. 2022 [citado 8 dic 2024]; 4:992176. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC9763629/
25. McElroy KG, Regan M. Vaginal Microbiota and Lubricant Use During Labor: Implications for Nursing Research, Practice, and Policy. SAGE Open Nursing [internet] 2016 [citado 8 dic 2024]; 2. Disponible en: https://journals.sagepub.com/doi/full/10.1177/2377960816662286
26. Jaspan HB, Mitchell CM, Happel AU. The vagina question: Can maternal vaginal fluid impact the infant gut microbiome and neurodevelopment? Cell Host Microbe. [internet] 2023 [citado 8 dic 2024]; 31(7):1084-6. Disponible en: https://www.cell.com/action/showPdf?pii=S1931-3128%2823%2900258-5
27. Aagaard K, Ma J, Antony KM, Ganu R, Petrosino J, Versalovic J. The placenta harbors a unique microbiome. Sci Transl Med. [internet] 2014 [citado 8 dic 2024]; 6(237):237ra65. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC4929217/
28. Argaw-Denboba A, Schmidt TSB, Di Giacomo M, Ranjan B, Devendran S, Mastrorilli E, et al. Paternal microbiome perturbations impact offspring fitness. Nature [internet] 2024 [citado 8 dic 2024]; 629, 652-9. Disponible en: https://www.nature.com/articles/s41586-024-07336-w
29 Veerus L, Blaser MJ, Sadovsky Y, Jašarevic E. Dad’s gut microbes matter for pregnancy health and baby’s growth. Nature [internet] 2024 [citado 8 dic 2024]; 629:536-7. Disponible en: https://www.nature.com/articles/d41586-024-01191-5