Authors

1Julio César de la Torre Montero, 2María Montealegre Sanz

Position

¹Enfermero. Máster en Investigación en Cuidados. Servicio de Oncología Médica. Hospital Clínico San Carlos, Madrid.²Enfermera. Máster en Investigación en Cuidados. Servicio de Oncología Médica. Hospital Clínico San Carlos, Madrid.

Contact address

Julio César de la Torre Montero. Servicio de Oncología Médica. Hospital Clínico San Carlos. C/ Profesor Martín Lagos, s/n. 28040 Madrid.

Contact email: jtorrem.hcsc@salud.madrid.org

Abstract

Objective: to explore whether the dynamic behavior of the venous blood stream is suitable, with the priority being the venous reflux,
following repeated blood draws as part of a clinical trial, in order to perform an extraction we consider to be clean and of quality for subsequent determinations.
Method: the population consisted of patients with ovarian cancer, brain glioblastoma and locally advanced breast cancer, with treatment as part of Phase I clinical trials, where the peripheral venous system is not pre-treated or damaged. 83 extraction sites were studied, within the first 24 hours of catheter insertion, eliminating from the study the first puncture site, where there is no prior preservation.
Results: regarding the ease of reflux, the heparinised route refluxed more easily in 82,9% of cases, with difficulty in 14,6% of cases, and did not reflux in 2,4% of cases. In salinized routes, it refluxed easily­ in 39,5% of cases, with difficulty in 55,8% of cases, and did not reflux in 4,7% of cases. Concerning the quality of the extracted sample, as measured by the hemolysis of the sample, from the routes maintained with heparinized saline solution, samples lysed in 19,5% of cases, and in routes maintained with saline solution, samples lysed in 39,5% of cases.
Conclusions: at low concentrations, sodium heparin (20 IU/ml) compared with saline solution reduces the problems associated with catheter reflux, increasing the number of peripheral catheters that refluxed easily while decreasing the degree of hemolysis of the sample. However, it should be noted that the routes do not remain in the same conditions as in the beginning past the first hours of canaliza­tion although they are maintained for a very short period of time, maxi­mum 24 hours.

Keywords:

blood collection; catheters; heparinizationsaline

Versión en Español

Título:

Heparinización versus salinización en catéteres periféricos cortos para extracciones de sangre en ensayos clínicos