Metas de Enfermería

Metas de Enfermería

SEPTIEMBRE 2014 N° 7 Volumen 17

Evidence of the efficacy of hyperoxygenated fatty acids in the prevention and treatment of wounds

Section: Featured Articles

How to quote

Carrera Castro C. Evidencia de la efectividad de ácidos grasos hiperoxigenados para prevención y tratamiento de heridas. Metas Enferm sep 2014; 17(7): 18-23.


Carmen Carrera Castro


Enfermera. Experta universitaria en Biotecnología aplicada a los alimentos, crecimiento celular y cáncer y nutrición artificial ambulatoria y domiciliaria. Unidad Quirúrgica y Medicina General. Hospital Ernest Lluch. Calatayud (Zaragoza).

Contact address

Carmen Carrera Castro. C/ Naranjo, 48. 11550 Chipiona (Cádiz).

Contact email: ccarrera@salud.aragon.es


Objetive: to learn about the best scientific evidence available about the efficacy of Hyperoxygenated Fatty Acids (HOFA) in the prevention and/or treatment of patients with high risk and/or cutaneous lesion.
Methodology: systematic review. A search for controlled and randomized clinical trials (CRTs) was conducted in PubMed, bvsalud (Medline, Ibecs, Lilacs), Cuiden, SciELO and Cochrane library plus, Summaries and Wounds Group Specialised trials register, with MeSH and DeCS thesaurus descriptors, and the free term: Hyperoxygenated Fatty Acids. Studies with adult and elderly patients were included, who had risk and/or alteration of cutaneous integrity, without idiomatic restriction, from the date indexed in biomedical databases until January, 1st, 2014.
Results: three CRTs were found, two for prevention and one for treatment of pressure ulcers (PUs), with high evidence level (A), and a strong level of recommendation: Level 1, according to the GRADE criteria (Grading of Recommendations Assessment, Development and Evaluation Working Group), conducted in Spain in the hospitalization and socio-sanitary settings.
Conclusion: the use of HOFA is recommended as a prevention and/or treatment measure for PUs in Stage 1, even though further future research is required in order to clarify the gaps existing in the knowledge and efficacy for the rest of wounds.


Hyperoxygenated Fatty Acids; wounds; pressure ulcers; prevention; scarring; reviewevidence

Versión en Español


Evidencia de la efectividad de ácidos grasos hiperoxigenados para prevención y tratamiento de heridas