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Metas de Enfermería

Metas de Enfermería

MAYO 2015 N° 4 Volumen 18

Detection of Adverse Drug Reactions in a mid-to-long-term-stay hospital

Section: Cover story

How to quote

Ibarzabal Lachada G. Reacciones adversas a medicamentos en un hospital de media-larga estancia. Metas Enferm may 2015; 18(4): 19-24.

Authors

Gotzone Ibarzabal Lachaga

Position

Enfermera

Contact address

Madalenbidea, 24. 48100 Mungia (Bizkaia).

Contact email: gotzone@kaixo.com

Abstract

Objective: adverse Drug Reactions (ADRs) represent a threat for the safety of hospitalized patients. The objective is to find out the incidence of Adverse Drug Reactions (ADRs) in a mid-
to-long-term stay hospital, to identify patient and ADR characteristics, and to determine ADR record in the Digital Clinical History prepared by professionals.
Method: a retrospective and descriptive study has been conducted in the Internal Medicine Department of the Hospital Gorliz (Biscay) from December, 1st, 2009 to December, 31st, 2011. With the relevant authorization by the Ethical Committee for Clinical Research from the Hospital Universitario Cruces, the competent authority, and the Hospital Gorliz management, there was access to the databases set up by the computer applications of digital clinical records: Global Clinic, Zaineri and eOsabide.
Results: the incidence of ADRs in patients hospitalized in this period was 13% (n= 238). ADRs were more frequent in male patients (57%), 40% of these appeared in 81-to-90-year old patients, and 95% were Type A reactions, mainly already known and described in the product specifications. The mean stay of patients with ADRs was significantly higher (P< 0.0001). The group of drugs for the digestive tract and metabolism was the cause for 31% of ADR cases.
227 ADR cases had been recorded in nursing reports, and 94 cases in clinical reports at hospital discharge.
Conclusions: polymedication, advanced age, and a prolonged hospitalization are associated with Adverse Drug Reactions.

Keywords:

Adverse Drug Reactions; mid-to-long-term stay hospital; patient safety; nursing record; prevention; Chronicity; Geriatric Nursing

Versión en Español

Título:

Reacciones adversas a medicamentos en un hospital de media-larga estancia

Artículo completo no disponible en este idioma / Full article is not available in this language

Bibliography

  1. Hakkarainen KM, Hedna K, Petxold M, Hägg S. Percentage of patients with preventable adverse drug reactions and preventavility of adverse drug reactions- A meta-analysis Plos One 2012;7:1-9
  2. Marcum ZA, Amuan ME, Hanlon JT, Aspinall SL, Handler SM, Ruby CM, Pugh MJP. Prevalence of unplanned hospitalisations caused by adverse drug reactions among older veterans. Am J Geriatr 2012; 60:34-41.
  3. Ponte ML, Ragusa M, Armenteros C, Wachs A. Relevancia de la farmacovigilancia hospitalaria en la práctica médica actual. Medicina 2013; 73:35-8.
  4. Real Decreto 1344/2007, de 11 de octubre, por el que se regula la farmacovigilancia de medicamentos de uso humano. [citado 16 abril 15]. Disponible en: http://www.aemps.gob.es/vigilancia/medicamentosUsoHumano/home.htm
  5. Madurga M, Soucheiron C. Buenas prácticas de farmacovigilancia: una propuesta. En: Grupo IFAS (ed.). Nuevas perspectivas de la farmacovigilancia en España y en la Unión Europea. Madrid: Jarpyo; 1998, p. 113-30.
  6. Berthoux E, Dufour C, Raharisondraibe E, Bonnefoy M. Preventable drug events in acute geriatric unit. Geriatr Psicol. Neuropsychiatr Vieil 2013;11:15-20.
  7. Piazza G, Nguyen TN, Cios D, Labreche M, Hohlfelder B, Fanikos J, et al. Anticoagulation-associated adverse drug events. Am J Geriatr 2011; 124:1136-42.
  8. Fernández Regueiro R, Fonseca Aizpuru E, López Colina G, Álvarez Uria A, Rodríguez Ávila E, Moris de la Tassa J. Prescripción inadecuada y efectos adversos a medicamentos en pacientes de edad avanzada. Rev Clin Esp 2011; 211:400-6.
  9. Ruiz B, García M, Aguirre U, Aguirre C. Factors predicting hospital readmissions relates to adverse drug reactions. Eur J Clin Pharmacol 2008; 64:715-22.
  10. Gea-Velázquez de Castro M, Aranaz-Andrés JM. Eventos adversos asociados a la asistencia del paciente pluripatológico ingresado en hospitales de crónicos. Med Clin 2010; 135:17-23.
  11. Pinzón JF, Maldonado C, Díaz JA, Segura O. Costos directos e impacto sobre la morbimortalidad hospitalaria de eventos adversos prevenibles a medicamentos en una institución de tercer nivel de Bogotá. Biomédica 2011; 31:307-15.
  12. Szlejf C, Farfel JM, Curiati JA, Barros E, Jacob-Filho W, Soares R. Medical adverse events in elderly hospitalized patients: a prospective study. Clinics 2012; 37:1247-52.
  13. Delgado E, Muñoz M, Montero B, Sánchez C, Gallagher PF, Cruz-Jentoft AJ. Prescripción inapropiada de medicamentos en los pacientes mayores: los criterios STOPP/START. Rev Esp Geriatr 2009; 44:273-79.
  14. Demissew BH, Wubeante YA, Pramil T. Prevalence and assessment of factors contributing to adverse drug reactions in wards of a tertiary care hospital, India. Ethiop J Health Sci 2013; 23:39-48.
  15. Caamaño F, Pedone C, Zuccalà G, Carbonin P. Socio-demographic factors related to the prevalence of adverse drug reaction at hospital admission in an elderly population. Arch Gerontol Geriatr. 2005; 40:45-52.
  16. Vila A, San José A, Roure C, Armadans L, Villardell M. Estudio multicéntrico prospectivo de reacciones adversas a medicamentos en pacientes ancianos hospitalizados. Med Clin 2003; 120:613-8.
  17. Zapatero A, Barba R, Ruiz JM, Emilio J, Marco J, Plaza S, Canora J. Acontecimientos adversos causados por medicamentos en pacientes ingresados en medicina interna. Rev Clin Esp 2010; 210:263-9.