Metas de Enfermería

Metas de Enfermería

SEPTIEMBRE 2015 N° 7 Volumen 18

Therapeutic hypothermia in managing newborns with hypoxic-ischemic encephalopathy

Section: Featured Articles

How to quote

Macarro Ruiz D, Sánchez Sánchez J, Toledano Luna M, Martínez Martín E, Martínez Galán P, García Rebollo MA. Hipotermia terapeútica en la asistencia al neonato con encefalopatía hipóxico isquémica. Metas Enferm sep 2015; 18(7): 6-12.


1Dolores Macarro Ruiz, 2Judith Sánchez Sánchez, 3Manuela Toledano Luna, 4Eduardo Martínez Martín, 5Paloma Martínez Galán, 6Miguel Ángel García Rebollo


1    Matrona. Hospital Ciudad de Coria (Cáceres).2    Matrona de Atención Primaria Centro de Salud María Ángeles López Gómez. Leganés (Madrid).3    Matrona. Hospital de Montilla (Córdoba). 4    Matrón. Hospital General de Segovia (Segovia).5    Matrona. Hospital Virgen de la Salud (Toledo).6    Matrón. Gerencia de Atención Primaria. Centro de Salud de Almaraz (Cáceres).

Contact address

Dolores Macarro Ruiz. C/ Atarazanas, 40. 10800 Coria (Cáceres).

Contact email: lola_maca@hotmail.com


Objective: to analyze the scientific evidence available about the circumstances previous to labour which precede neonatal asphyxia in time, and about the protocol for whole-body moderate hypothermia in order to prevent or reduce the brain damage associated with perinatal hypoxic-ischemic aggression.
Method: an integrative review where a literature search was conducted in the following databases: Medline, Cinahl, Cochrane Plus, Cuiden, Cuidatge, Bireme and Enfispo. The search was limited to the Spanish and English languages, and there was no limitation in years. As inclusion criteria, the following were selected: systematic reviews, meta-analyses, non-systematic reviews, and clinical trials on the subject, including original studies published up to this date.
Results: perinatal hypoxic-ischemic encephalopathy is one of the most dramatic and unexpected events that can affect a newborn (NB) and his/her family. Different studies have demonstrated that at 18 months of age, therapy with hypothermia has reduced significantly the number of deaths and major disabilities vs. traditional therapy, as well as the benefits offered by whole-body cooling and by selective brain cooling.
Conclusions: the evidence available supports the use of therapeutic hypothermia in managing newborns with hypoxic-ischemic encephalopathy.


Perinatal asphyxia; hypoxic-ischemic encephalopathy; therapeutic hypothermia; neuroprotection; newbornneonate

Versión en Español


Hipotermia terapéutica en la asistencia al neonato con encefalopatía hipóxico isquémica