Authors

Liz Paola Flecha Galeano1, Gladys Mabel Maidana de Larroza2

Position

1Máster. Farmacia Hospital Día. Hospital Central. Instituto de Previsión Social. Paraguay2Doctora. Departamento de Farmacia. Facultad de Ciencias Químicas. Universidad Nacional de Asunción. Paraguay

Contact address

Gladys Mabel Maidana de Larroza. 11 Proyectadas N° 557 entre 14 de mayo y 15 de agosto. 001016 Asunción (Paraguay).

Contact email: glamaida73@gmail.com

Abstract

Objective: to understand the most prevalent adverse reactions to drugs administered during outpatient intravenous chemotherapy to oncology patients at Day Hospital.
Methods: a descriptive longitudinal study conducted at the Day Hospital of the Hospital Central del Instituto de Previsión Social of Paraguay, between April and May 2021. Those patients who underwent at least three chemotherapy sessions during the period studied were recruited and followed up. Sociodemographic and clinical data were recorded, as well as those relative to their cancer diagnosis, chemotherapy treatment, and adverse drug reactions (ADRs). Data were collected through interviews and medical records. Descriptive analysis.
Results: the average age of patients was 50 years; 73% were female. The most prevalent type of tumour was breast cancer (42.6%), followed by colorectal cancer (19.1%). With 551 ADRs detected, the most prevalent events recorded were gastrointestinal (34.1%), dermatological (22.7%) and neurological (16.3%). Paclitaxel was the drug most prescribed; and 100% of patients presented ADRs.
Conclusions: all patients experienced ADRs secondary to treatment with intravenous chemotherapy, and the most common were gastrointestinal and dermatological events.

Keywords:

cancer; chemotherapy; adverse drug reaction

Versión en Español

Título:

Reacciones adversas a los medicamentos en pacientes oncológicos con quimioterapia intravenosa ambulatoria